A fistula for measurement of bile flow and composition in the dog.

Many types of biliary fistula have been created for the study of biliary secretion in the experimental perspex block'-animal. Most of these interfere considerably with n6' 5/e r , normal physiological function, either by bypassing r the sphincter of Oddi, or more commonly by failing body to maintain the enterohepatic circulation of bile. of Thureborn (1963) has shown that interruption of the enterohepatic circulation alters the volume and 0ockli7 c $crm composition of liver bile. Moreover the enterohepatic kper co/let dewcea circulation is modified by the activity of the gall bladder and the sphincter of Oddi. The apparatus A which we have used in the dog is easy to construct, causes minimal interference with normal biliary mechanics, and has proved successful in studies of bile flow and composition.